DICP. Applies only to oral form of both agents. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. Minor/Significance Unknown. DOSAGE AND ADMINISTRATION: Venofer must only be administered intravenously either by slow injection or by infusion. Slowing the infusion rate may alleviate symptoms. Modify Therapy/Monitor Closely. By clicking send, you acknowledge that you have permission to email the recipient with this information. Administer Venofer early during the dialysis session (generally within the first hour). Fulminant symptoms may include general paleness, confusion or episodes of passing out. Slow or stop the infusion if adverse reactions occur. Applies only to oral form of both agents. 1) Ganzoni AM. Chandler G, Harchowel J, Macdougall I. sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Minor/Significance Unknown. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when Venofer is injected. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Kumpf VJ, Holland EG. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abacb7fa-2fc2-471e-9200-944eeac8ca2a. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] -Volume of parenteral iron product req'd (mL) = [Iron deficit (mg)] / C(mg/mL) Final calculations: -Hgb iron deficit (mg) = weight (kg) x (14 - Hgb) x (2.145) -Volume of product required (mL) = [weight (kg)x (14 - Hgb) x (2.145)] / C Where C= concentration of elemental iron (mg/ml) in the product being used: Iron dextran: 50 mg/mL. Use Caution/Monitor. 4)Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Avoid or Use Alternate Drug. Suggested regime: Prescribing instructions Prescribing a single/first dose: Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. When administered via infusion, dilute up to 750 mg of iron in no more than 250 mL of sterile 0.9% sodium chloride injection, USP, such that the concentration of the infusion is not less than 2 mg of iron per mL and administer over at least 15 minutes. Give each dose as 750 mg for a total cumulative dose not to exceed 1500 mg of iron per course. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Minor/Significance Unknown. Iron Deficiency in Heart Failure - Home - American College of Cardiology Written by ASHP. Applies only to oral form of both agents. If you log out, you will be required to enter your username and password the next time you visit. Use Caution/Monitor. Minor/Significance Unknown. Iron Deficit - Multi-Calc - GlobalRPH - Medical Calculators, Clinicians Monitor Closely (1)famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. HOW TO USE: This medication is given by injection into a vein as directed by your doctor. Modify Therapy/Monitor Closely. Oral iron therapy is the first method while IV therapy comes in place when there are contraindications or the body doesnt respond to the oral one. Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. If dose exceeds 20mg/kg it should be rounded down to 20mg/kg OR administration of the total dose has to be split and given 7 days apart. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. Taking the case of a patient weighing 75 kg (165.3 lbs) with a target hemoglobin value of 13 g/dL (130 g/L or 8.07 mmol/L), an actual hemoglobin of 9.5 g/dL (95 g/L or 5.9 mmol/L) and iron stores of 500 mg, the iron deficit is: Iron deficit = 75 x (13 9.5) x 2.4 + 500 = 1,130 mg. Drug: Comments: A: Acyclovir 1: Dose using a 40% adjusted body weight; Amikacin 2: Dose using a 40% adjusted body weight; Amphotericin B (liposomal) 3 Consider capping body weight to 100 kg; Atracurium 4: Dose using ideal body weight; The use of ideal body weight has been shown to be associated with a more predictable muscle strength recovery within 60 minutes and a lack of need for antagonism . Use Caution/Monitor. Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Andreas M. Ganzoni, MD, is a physician and researcher in the internal medicine department at the University of Zurich in Zurich, Switzerland. Monofer 100mg/ml solution for injection/infusion - Summary of Product Maintain a well-balanced diet, and follow any dietary guidelines as directed by your doctor. 2. iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Applies only to oral form of both agents. The elemental iron product used is Iron sucrose 20 mg/mL. Compare formulary status to other drugs in the same class. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. Use Caution/Monitor. Serious hypersensitivity reactions, including anaphylactic-type reactions, some of which have been life-threatening and fatal, have been reported in patients receiving Venofer. To view formulary information first create a list of plans. Where: Medicine concentration Amount of active substance per a given volume of your drug. Administer Venofer early during the dialysis session (generally within the first hour). Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session [see How Supplied/Storage and Handling (16.2).] Applies only to oral form of both agents. deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. informational and educational purposes only. Use Caution/Monitor. 2010niferex-hytinic-polysaccharide-iron-342160Drugs, You are being redirected to This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Use alternatives if available. This information is not individual medical advice and does not substitute for the advice of your health care professional. If we don't have the calculator you need then tell us the details and we'll make it for you. No additional iron to replenish stores. Manage and view all your plans together even plans in different states. Maximum single dose of iron sucrose to be given at a time in Non-dialysis CKD patients is 500 mg but with limited experience. Venofer Dosing and Administration in the colostrum of 10 iron deficient breastfeeding women who were 2 to 3 days postpartum and received a single dose of 100 mg of intravenous iron . prescription products. Pregnancy: Risk Summary-Clinical Considerations. Ensure the Intravenous Iron Checklist (see trust guideline) has been completed. On the other hand, slow decreases, such as that in chronic occult gastrointestinal bleeding are often difficult to diagnose. Applies only to oral form of both agents. Venofer (iron sucrose) 20 mg iron / ml, solution for injection or 2 Protocol for Intravenous iron sucrose - Venofer 2.1 Dosage The total cumulative dose of Venofer should be calculated using the table below. Do not administer Venofer to patients with iron overload. The dosage of Venofer is expressed in mg of elemental iron. Burns DL, Mascioli EA, Bistrian BR. 2022 American Regent, Inc.PP-VE-US-0016 (v6.0)1/2022. Use Caution/Monitor. Monitor Closely (1)pantoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Then enter the value of the Dosage and choose the unit of measurement from the drop-down menu. The recipient will receive more details and instructions to access this offer. Use Caution/Monitor. (3) Known hypersensitivity to Venofer. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Use Caution/Monitor. Hollands J, Foote E, Rodriguez A. Applies only to oral form of both agents. Calculates iron deficit for dosing iron. Results: Twelve children (6 females) aged 1.2-14 years (median age 8.9 years) received at least one dose of . Each mL contains 20 mg of elemental iron. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. Aranesp (darbepoetin alfa) | Dosing Considerations Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of oxytetracycline by inhibition of GI absorption. Applies only to oral form of both agents. Parenteral Iron Replacement For Iron Deficiency Anemia Calculator Serious - Use Alternative (1)iron sucrose decreases levels of demeclocycline by inhibition of GI absorption. Deferasirox chelates iron. Injection: 50 mg/2.5 mL, 100 mg/5 mL, or 200 mg/10 mL (20 mg/mL) in single-dose vials. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. INDICATIONS AND USAGE: Intravenous or intramuscular injections of INFeD are indicated for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. 0.5 mg/kg (not to exceed 100 mg/dose) diluted to a concentration of 1 to 2 mg/mL in 0.9% sodium chloride IV over 5 to 60 minutes Administer every 4 weeks for 12 weeks Do not dilute to concentrations below 1 mg/mL Comments: Treatment may be repeated if necessary. 5. Iron Sucrose Dosage Guide + Max Dose, Adjustments - Drugs.com Use Caution/Monitor. Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. J Lab Clin Med. Other indications for IV are pregnancy iron deficiency, chronic renal impairment or need for rapid repletion. Iron sucrose: 20 mg/mL. Iron Deficiency Anemia: Periodic hematologic determination (hemoglobin and hematocrit) is a simple and accurate technique for monitoring hematological response, and should be used as a guide in therapy. Applies only to oral form of both agents. Observed Hb = the patients current hemoglobin in g/dl. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. iron sucrose increases levels of calcium gluconate by enhancing GI absorption. Applies only to oral form of both agents. The Ganzoni equation used by the iron deficiency calculator is the following: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores. Mean Corpuscular Hemoglobin Concentration (MCHC) Calculator, Red Blood Cell (RBC) Indices Calculator, Iron Deficiency In Pregnancy Calculator. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of iron sucrose by inhibition of GI absorption. Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. Venofer treatment may be repeated if necessary. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time. Intravenous iron-dextran: therapeutic and experimental possibilities. Intravenous Iron Therapy in Patients with Iron Deficiency Anemia ------------------------------------------------------------------------- Ferric Carboxymaltose [ Injectafer ] Elemental iron: Injectafer contains 50 mg of elemental iron - 750 mg/15 mL [package insert] Indications: Injectafer is indicated for the treatment of iron deficiency anemia in adult patients: who have intolerance to oral iron or have had unsatisfactory response to oral iron; who have non-dialysis dependent chronic kidney disease. To provide clinicians with evidence-based guidance for iron therapy dosing in patients with iron deficiency anemia (IDA), we conducted a study examining the benefits of a higher cumulative dose of intravenous (IV) iron than what is typically administered. Applies only to oral form of both agents. Assure stable intravenous access to avoid extravasation. Give each dose as 750 mg for a total cumulative dose of 1500 mg of iron per course. The dosage of iron sucrose is expressed in mg of elemental iron. Diluted with 0.9% Sodium Chloride Injection at concentrations of 1 to 2 mg/mL, 2 doses of 300 mg/250 mL over 1.5 hrsplus1 dose of 400 mg/250 mL over 2.5 hrs. Can't find what you need? iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. There is in depth information below the form on the method used and on the result provided. Contact the applicable plan Applies only to oral form of both agents. Use Caution/Monitor. This drug is available at a higher level co-pay. rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Deferasirox chelates iron. Minor (1)iron sucrose, captopril. Minor/Significance Unknown. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. *Administer early during the dialysis session. Applies only to oral form of both agents. Applies only to oral form of both agents. PDF Venofer - Food and Drug Administration Minor/Significance Unknown. PDF Treatment Guideline - Gloucestershire Royal Hospital concentration of elemental iron (mg/ml) in the product being used: This calculator will help pinpoint potential causes of anemia based on an automated flowchart approach. Here are the steps to follow for using this drug dosage calculator: First, enter the value of your Weight and choose the unit of measurement from the drop-down menu. Symptoms of a serious allergic reaction may include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Use Caution/Monitor. Adult Patients with Hemodialysis Dependent-Chronic Kidney Disease (HDD-CKD): Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Serious - Use Alternative (1)iron sucrose decreases levels of ofloxacin by inhibition of GI absorption. Monitor Closely (1)ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The primary endpoint was the proportion of patients with . Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. Applies only to oral form of both agents. Diagnosis and management of iron deficiency anaemia: a clinical update. Maximum infusion rate: 100 mg / hour (Slow infusion rate of iron sucrose is recommended to minimize adverse reactions, especially hypotension) Frequency of infusion: Dose may be repeated up to 3 times weekly to provide total iron dose. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). PDF Iron dosing and administration in adults backgrounder Monitor Closely (1)deferoxamine decreases levels of iron sucrose by inhibition of GI absorption. Sodium ferric gluconate (Ferrlecit) 62.5 mg . Dilute Venofer in a maximum of 250 mL of 0.9% NaCl [see How Supplied/Storage and Handling (16.2).] Venofer has not been studied in patients younger than 2 years old. Applies only to oral form of both agents. Minor/Significance Unknown. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and *Repeat dose if iron deficiency anemia reoccurs. Applies only to oral form of both agents. We first individually analyzed 5 clinical studies, averaging the total iron deficit across all patients utilizing a . Talk to your pharmacist for more details.During pregnancy, this medication should be used only when clearly needed. You may need extra iron because of blood loss during kidney dialysis. If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. 1970; 100(7):301-3. Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Ganzoni AM. Access your plan list on any device mobile or desktop. omeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. FERAHEME Dosing & Administration - Feraheme Discuss the risks and benefits with your doctor.This medication passes into breast milk. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Calculation of the Total Iron Deficit - Alternative equation iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. . Venofer [package insert]. David McAuley, Pharm.D. Human studies not conducted. Applies only to oral form of both agents. Applies only to oral form of both agents. nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. and formulary information changes. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Monitor Closely (1)lansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. The initial hemoglobin rise is more rapid with parenteral iron but on the long term (12 weeks), both therapies reach similar levels of hemoglobin. Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Separate dosing of tetracyclines from these products. PDF GUIDELINES FOR IRON INFUSION USE IN ADULTS - Brockville General Hospital Your doctor will do laboratory tests to monitor your response. Interaction only with oral iron administration. cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. 1 ,*. aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. Applies only to oral form of both agents. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. -Hgb deficit (grams) = Hgb deficit (g/dL) x blood volume (dL) -Iron deficit (mg) = Hgb deficit (grams) x 3.3 (mg Fe/g Hgb) [Note: 3.3 x 0.65 = 2.145] Volume of iron sucrose needed = 60 x (14 - 8) x (2.145) 20 = 38.6 mL . Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later. Intravenous iron-dextran: therapeutic and experimental possibilities [in German] Schweiz Med Wochenschr. iron sucrose will decrease the level or effect of sarecycline by inhibition of GI absorption. iron sucrose increases levels of calcium carbonate by enhancing GI absorption. The dosage of Venofer is expressed in mg of elemental iron. 200-800 mg/kg (2-8 mL/kg) every 3-4 weeks. Applies only to oral form of both agents. Schweiz Med Wochenschr; 100(7):301-3. Official Journal of the International Society of Nephrology. The incidence of adverse events with the 400- and 500-mg doses administered as a 2-hour . Do not dilute to concentrations below 1 mg/mL [see How Supplied/Storage and Handling (16.2).] Use Caution/Monitor. Inspect parenteral drug products visually for the absence of particulate matter and discoloration prior to administration. Venofer Injection Prescribing Information - Drugs.com Monitor for signs and symptoms of hypotension following each Feraheme infusion. Assessing new treatment options. iron sucrose increases levels of calcium citrate by enhancing GI absorption. Clinical calculators for obstetrics and gynaecology - calculosaurus Applies only to oral form of both agents. Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Copyright 2021 GlobalRPH - Web Development by, Calculation of the Total Iron Deficit Alternative equation. Iron sucrose can also be mixed in a saline solution and given through an IV over a longer time.Your dosage and length of treatment are based on your medical condition, age, and response to treatment. Applies only to oral form of both agents. Do not administer Venofer to patients with evidence of iron overload. Monitor Closely (1)iron sucrose decreases levels of thyroid desiccated by inhibition of GI absorption. Applies only to oral form of both agents. . Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. This health tool computes the required parenteral iron replacement dose for the iron deficit extracted from the patient weight and hemoglobin level from complete blood count test. Applies only to oral form of both agents. A target haemoglobin value is also input so iron deficit can be determined according to a specified individual target. Total cumulative Venofer dose = number of 100mg ampoules for Hb increase. The Ganzoni equation is: Total iron deficit (mg) = Weight in kg x (Target Hb - Actual Hb in g/dL) x 2.4 + Iron stores In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron - carboxymaltose); dexlansoprazole will decrease the level or effect of iron sucrose by increasing gastric pH. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. Dosage Calculator - [100% Free] - Calculators.io Studies in monkeys showed concurrent use with calcium, aluminum, or iron caused significantly decreased plasma levels. Monitor Closely (1)nizatidine will decrease the level or effect of iron sucrose by increasing gastric pH. Serious - Use Alternative (1)iron sucrose decreases levels of mycophenolate by inhibition of GI absorption. Discard unused portion. Contraindicated. Parenteral iron supplementation. Modify Therapy/Monitor Closely. iron sucrose, captopril. DailyMed - VENOFER- iron sucrose injection, solution Parenteral Iron Replacement For Anemia Calculator - MDApp The total amount of INFeD in mL required to treat the anemia and replenish iron stores may be approximated as follows: Adults and Children over 15 kg (33 lbs): See Dosage Table. There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14 [see How Supplied/Storage and Handling (16.2). iron sucrose, benazepril. Most Venofer (Iron Sucrose Injection) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Applies only to oral form of both agents. Use Caution/Monitor. Med J Aust; 193(9):525-32. calcium carbonate decreases levels of iron sucrose by inhibition of GI absorption. Use Caution/Monitor. Do Not Copy, Distribute or otherwise Disseminate without express permission. Ferric gluconate: 12.5 mg/mL Schrier SL, Mentzer WC, Landaw SA. Administer Venofer only intravenously by slow injection or by infusion. Consult your doctor for more details.Remember that it is best to get your vitamins and minerals from food whenever possible. Oral and parenteral products - see background option for oral products. Recommended dosage for patients weighing less than 50kg (110lb): Give Injectafer in Minor/Significance Unknown. Human studies not conducted. This topic . If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule. Applies only to oral form of both agents. 1982;13(4):309-21. Applies only to oral form of both agents. Ferritin and transferrin are also recommended monitoring . Adult Dosage and Administration: The recommended dosage of Ferrlecit for the repletion treatment of iron deficiency in hemodialysis patients is 10 mL of Ferrlecit (125 mg of elemental iron). Applies only to oral form of both agents. The dosage of Venofer is expressed in mg of elemental iron. Monitor Closely (1)cimetidine will decrease the level or effect of iron sucrose by increasing gastric pH. Only administer Feraheme as an intravenous infusion over at least 15 minutes and only when personnel and therapies are immediately available for the treatment of anaphylaxis and other hypersensitivity reactions. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations.
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